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Effect of catestatin on ventricular arrhythmia in acute myocardial infarction in rats(PDF)

Journal of Xian Jiaotong University(Medical Sciences)[ISSN:1671-8259/CN:61-1399/R]

Issue:
2018年5期
Page:
644-647
Research Field:
基础研究
Publishing date:

Info

Title:
Effect of catestatin on ventricular arrhythmia in acute myocardial infarction in rats
Author(s):
FANG Yuan SHU Juan LIU Yang Cao Yu-meng
Department of Cardiovascular Medicine, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, China
Keywords:
acute myocardial infarction catestatin ventricular arrhythmia ventricular vulnerable period effective refractory period
CLC:

PACS:
R541.4
DOI:
10.7652/jdyxb201805007
DocumentCode:

Abstract:
ABSTRACT: Objective   To explore the correlation between the catestatin (CST) level and ventricular arrhythmia (VA) in acute myocardial infarction (AMI). Methods   Sixty male rats were randomly divided into sham group (n=20) and AMI group (n=40). Myocardial infarction was produced by ligation of the left anterior descending coronary artery. Thirty-six rats in AMI groupsurvived. Both groups were detected for plasma CST level, ventricular arrhythmia susceptibility, ventricular vulnerable period and effective refractory period so as to evaluate the effect of CST on VA in AMI. Results    Compared with that in sham group, LVEF reduced significantly in AMI group (P<0.01), while LVEDD, LVESD and CST increased (P<0.01). After programmed electrical stimulation, in AMI group VA was induced in 31 rats (86.1%) (P<0.01), ventricular vulnerable period extended, and effective refractory period shortened (P<0.01). Logistic regression analysis showed that decreased LVEF and increased CST were the independent risk factors of VA in AMI rats (P<0.01 to P<0.05). Conclusion The CST level is an independent risk factor for VA in AMI; therefore, it can be used to evaluate the prognosis of AMI.

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Last Update: 2018-09-29