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Factors affecting survival of patients with amyotrophic lateral sclerosis(PDF)

Journal of Xian Jiaotong University(Medical Sciences)[ISSN:1671-8259/CN:61-1399/R]

Issue:
2018年5期
Page:
639-643
Research Field:
肌萎缩侧索硬化症专题
Publishing date:

Info

Title:
Factors affecting survival of patients with amyotrophic lateral sclerosis
Author(s):
KANG Li12 HU Fang-fang1 JIN Jiao-ting1 QIN Xing1 JIA Rui1 LIU Xiao1 ZHOU Qing-qing1 DANG Jing-xia1
1. Department of Neurology, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061; 2. State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China
Keywords:
amyotrophic lateral sclerosis survival analysis diagnostic delay time progression rate
CLC:

PACS:
R74
DOI:
10.7652/jdyxb201805006
DocumentCode:

Abstract:
ABSTRACT: Objective   To investigate the relationship between clinical features and survival time in amyotrophic lateral sclerosis (ALS) patients. Methods   For this study we enrolled 101 ALS patients who visited Department of Neurology, the First Affiliated Hospital of Xian Jiaotong University, from March 2010 to December 2015 and met the revised El Escorial Criteria. We documented the clinical features known up to the time of diagnosis, such as age of onset, BMI, body part of onset, diagnostic delay time, Ellis score, ALSFRS-r, ΔALSFRS-r, time from onset to second part involved and categories of diagnostic certainty. All the patients were regularly followed up every three months clinically or by phone. The clinical features mentioned above were analyzed for survival probability using the univariate and multivariate survival analyses. Results   ① Univariate log-rank test results: age at onset (HR 1.556, 95% CI 1.005-2.409, P=0.047), diagnostic delay time (HR 0.227, 95% CI 0.134-0.383, P<0.001), ΔALSFRS-r (HR 2.300, 95% CI 1.462-3.617, P<0.001), time from onset to second part involved (HR 0.593, 95% CI 0.377-0.934, P=0.024), and categories of diagnostic certainty (HR 1.709, 95% CI 1.065-2.743, P=0.026) were correlated to the survival time. ② Multivariate Cox regression test results: diagnostic delay time (HR 0.948, 95% CI 0.912-0.985, P=0.006) and ΔALSFRS-r (HR 2.146, 95% CI 1.538-2.995, P<0.001) were correlated to the survival time. Conclusion   Diagnostic delay time and ΔALSFRS-r are independent factors that affect the survival time in ALS.

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Last Update: 2018-09-29