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Correlation between compound muscle action potential amplitude and revised amyotrophic lateral sclerosis functional rating scale in amyotrophic lateral sclerosis(PDF)

Journal of Xian Jiaotong University(Medical Sciences)[ISSN:1671-8259/CN:61-1399/R]

Issue:
2018年5期
Page:
634-638
Research Field:
肌萎缩侧索硬化症专题
Publishing date:

Info

Title:
Correlation between compound muscle action potential amplitude and revised amyotrophic lateral sclerosis functional rating scale in amyotrophic lateral sclerosis
Author(s):
QIN Xing JIN Jiao-ting HU Fang-fang KANG Li LIU Xiao JIA Rui ZHAO Xing ZHANG Rong-hua DANG Jing-xia
Department of Neurology, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, China
Keywords:
amyotrophic lateral sclerosis (ALS) compound muscle action potential (CMAP) Revised Amyotrophic Lateral Sclerosis Functional Rating Scale (ALSFRS-r)
CLC:

PACS:
R74
DOI:
10.7652/jdyxb201805005
DocumentCode:

Abstract:
ABSTRACT: Objective   To explore the correlation between compound muscle action potential (CMAP) amplitude and Revised Amyotrophic Lateral Sclerosis Functional Rating Scale (ALSFRS-r) in amyotrophic lateral sclerosis (ALS). Methods   Standard motor nerve conduction studies were performed in 258 ALS patients. We analyzed the decrease of CMAP amplitude in different motor nerves in the four limbs and discussed the relationship between the CMAP amplitude and ALSFRS-r score and the score of each subitem. Results   Motor nerve conduction abnormalities were present in a majority of the patients with decreased CMAP amplitude in the median nerve, ulnar nerve, peroneal nerve and tibial nerve as the most common form (14.80%-59.90%),followed by prolonged DML (1.83%-25.00%), absence of CMAP (2.23%-10.55%), and decreased MCV (0-14.36%). Significant positive correlation was found between CMAP amplitude of the median, ulnar, peroneal and tibial nerves and ALSFRS-r (r=0.333, P<0.001; r=0.284, P<0.001; r=0.189, P=0.002; r=0.253, P<0.001). Logistic regression analysis showed significant correlation between the ALSFRS-r score and the median and tibial nerve CMAP amplitude. Logistic regression analysis showed significant correlation between the cervical enlargement score of ALSFRS-r and median nerve CMAP amplitude, the lumbar enlargement score of ALSFRS-r and CMAP amplitude of peroneal and tibial nerves, but no correlation with ulnar nerve CMAP amplitude. Conclusion    Motor nerve conduction is abnormal in a majority of ALS patients with decreased CMAP amplitude as the most common form. It is a validated and objective electrophysiological instrument for monitoring the severity of disability in ALS patients. The decrease of CMAP amplitude in different motor nerves has the same evaluation effect with the subscale scores of ALSFRS-r in cervical enlargement and lumbar enlargement in judging the degree of muscle dysfunction.

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Last Update: 2018-09-29