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Optimization of cognitive scales of executive dysfunction in amyotrophic lateral sclerosis patients(PDF)

Journal of Xian Jiaotong University(Medical Sciences)[ISSN:1671-8259/CN:61-1399/R]

Issue:
2018年5期
Page:
629-633
Research Field:
肌萎缩侧索硬化症专题
Publishing date:

Info

Title:
Optimization of cognitive scales of executive dysfunction in amyotrophic lateral sclerosis patients
Author(s):
JIN Jiao-ting HU Fang-fang QIN Xing KANG Li JIA Rui LIU Xiao SHANG Su-hang LIU Chen-yu WANG Liang ZHANG Rong-hua DANG Jing-xia
Department of Neurology, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, China
Keywords:
amyotrophic lateral sclerosis executive dysfunction diagnostic efficiency MOCA executive function rapid verbal retrieval (RVR) Wechsler Adult Intelligence Scale (WAIS) frontal assessment battery (FAB)
CLC:

PACS:
R74
DOI:
10.7652/jdyxb201805004
DocumentCode:

Abstract:
ABSTRACT: Objective   To screening scales that can reflect the executive function impairments in amyotrophic lateral sclerosis (ALS) patients and determine their reference value. Methods    We compared MOCA executive function, rapid verbal retrieval (RVR), Wechsler Adult Intelligence Scale (WAIS) and Frontal Assessment Battery (FAB) between ALS patients and control subjects to determine whether ALS patients have executive dysfunction. ROC curve was adopted to screen out the sensitive executive scales from WAIS, RVR (animals), RVR (fruits), RVR (vegetables), FAB, words beginning with "da" and MOCA executive function. Results    The scores of MOCA executive function, RVR, WAIS and FAB were lower in ALS patients than in control subjects (P<0.05). Compared with controls, ALS patients had poor performance in MOCA executive function, RVR (animals), RVR (fruits), RVR (vegetables), forward and backward in WAIS, conceptualization, uttering words beginning with "da", procedural control, sensitivity to interference, inhibitory control in FAB (P<0.05). However, there were not significant differences in words beginning with "fa" and autonomy in FAB (P>0.05). In order to detect executive dysfunction in ALS, the diagnostic efficacy was WAIS, RVR (animals), FAB, words beginning with "da", RVR (fruits), RVR (vegetables), and MOCA executive function in descending order. Conclusion   26.74% of the ALS patients have executive dysfunction. When executive dysfunction is screened in ALS patients, WAIS, RVR (animal), FAB have high diagnostic efficacy.

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Last Update: 2018-09-29