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Split leg phenomenon in amyotrophic lateral sclerosis(PDF)

Journal of Xian Jiaotong University(Medical Sciences)[ISSN:1671-8259/CN:61-1399/R]

Issue:
2018年5期
Page:
620-623
Research Field:
肌萎缩侧索硬化症专题
Publishing date:

Info

Title:
Split leg phenomenon in amyotrophic lateral sclerosis
Author(s):
HU Fang-fang JIN Jiao-ting QIN Xing KANG Li JIA Rui LIU Xiao LIU Chen-yu ZHANG Rong-hua WANG Liang DANG Jing-xia
Department of Neurology, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, China
Keywords:
amyotrophic lateral sclerosis (ALS) split leg compound muscle action potential (CMAP) nerve conduct study
CLC:

PACS:
R741
DOI:
10.7652/jdyxb201805002
DocumentCode:

Abstract:
ABSTRACT: Objective? ?To analyze CMAP amplitude of tibial nerve and peroneal nerve in ALS, and elucidate the split leg phenomenon and clinical value. Methods?? Compound muscle action potentials recorded from extensor digitorum brevis and abductor muscle were analyzed in 88 lower-leg involved ALS patients, 100 normal controls and 24 lumbar spondylopathy patients. Results? ?① The CMAP amplitude of tibial nerve were higher in ALS than that in spondylopathy patients [(7.06±3.86)mV vs. (3.31±1.72)mV, P<0.001], and the denervation potentials were greater in tibialisanterior muscle than gastrocnemius muscle (χ2=61.70, P<0.001); ② SLI was inferior in lower leg involved ALS patients compared with normal controls and lumbar spondylopathy patients (P<0.001), but SLI had no difference between normal controls and lumbar spondylopathy patients(P=0.023); ③ SLI was not releted to disease duration, ALSFRS-r score and progression rate (P>0.05); ④ The best cutoff value of SLI was 0.634, sensitivity=63.4% (95% CI=44.68%-84.37%), specificity=75% (95% CI=61.03%-77.69%), the positive predictive value=88.2%. Conclusion? ?The split leg phenomenon is a specific neuroelectrophysiological feature that appears in the early stage of disease in lower limb-involved ALS patients, which can be used as an electrophysiological marker for early diagnosis of ALS.

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Last Update: 2018-09-27