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Clinical manifestations and advances in diagnosis and treatment of amyotrophic lateral sclerosis(PDF)

Journal of Xian Jiaotong University(Medical Sciences)[ISSN:1671-8259/CN:61-1399/R]

Issue:
2018年5期
Page:
613-619
Research Field:
专家述评
Publishing date:

Info

Title:
Clinical manifestations and advances in diagnosis and treatment of amyotrophic lateral sclerosis
Author(s):
DANG Jing-xia
Department of Neurology, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, China
Keywords:
sporadic amyotrophic lateral sclerosis neurophysiological diagnosis diagnostic criteria upper/lower motor neuron
CLC:

PACS:
R74
DOI:
10.7652/jdyxb201805001
DocumentCode:

Abstract:
ABSTRACT: Amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease, mainly affects the corticospinal tract, brainstem and spinal cord anterior horn. Its clinical characteristics include progressive muscle weakness, atrophy, fasciculation, bulbar palsy and signs of pyramidal tract damage, which eventually lead to dysphagia and respiratory muscle weakness and death from respiratory failure. Frontotemporal dementia (FTD) occurs in approximately 15% of ALS patients. This article describes the clinical characteristics, survival time and influencing factors of ALS. It reviews the recent advances in diagnostic criteria, neurophysiological diagnosis and treatment of ALS. It is important to emphasize the early diagnosis of ALS. Clinicians should improve their understanding of the disease and provide proper treatment.

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Last Update: 2018-09-27