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KCa3.1: A potential therapeutic target for cardiovascular diseases(PDF)

Journal of Xian Jiaotong University(Medical Sciences)[ISSN:1671-8259/CN:61-1399/R]

Issue:
2013年第2期
Page:
139-143
Research Field:
专家述评
Publishing date:

Info

Title:
KCa3.1: A potential therapeutic target for cardiovascular diseases
Author(s):
DENG Xiu-ling
Department of Physiology and Pathophysiology, Medical School of Xi’an Jiaotong University, Xi’an 710061, China
Keywords:
intermediate-conductance Ca2+-activated K+ channel (KCa3.1) atherosclerosis restenosis cardiac fibrosis therapeutic target
CLC:

PACS:
R331
DOI:
10.7652/jdyxb201302001
DocumentCode:

Abstract:
ABSTRACT:  The intermediate-conductance Ca2+-activated K+ channel (KCa3.1) was first discovered in erythrocytes. The mRNA and protein levels of KCa3.1 are upregulated in numerous types of cells contributing to the development of cardiovascular diseases, such as activated T cells, B cells, macrophages and platelets, mitogen-stimulated vascular smooth muscle cells, and fibroblasts, which suggests a possible role for the channel in atherosclerosis, restenosis and cardiac fibrosis. This article reviews the structure, modulation characteristics, physiological and pathophysiological roles of KCa3.1 in regulating membrane potential and calcium signaling in cells, and discusses KCa3.1 blocker as a potential therapeutic target for cardiovascular diseases.

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Last Update: 2013-02-27